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Astrocyte Mitochondrial UCP4 Reprograms Neuronal Network Oscillations via GDNF-Dependent K+-Ca2+ Signaling in Alzheimer’s Disease Mice

Astrocyte Mitochondrial UCP4 Reprograms Neuronal Network Oscillations via GDNF-Dependent K+-Ca2+ Signaling in Alzheimer’s Disease Mice

August, 2026

A recent study published in Cells investigates the therapeutic potential of targeting astrocyte mitochondria in a mouse model of Alzheimer’s disease. The authors demonstrate that overexpression of the mitochondrial protein UCP4 in astrocytes restores several aspects of neuronal and network function, even...

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