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Oliver Burman, Gerardo Marsella, Angelo Di Clemente, Luigi Cervo
The effect of exposure to low frequency electromagnetic fields (EMF) as an integral part of the housing system on anxiety-related behaviour, cognition and welfare in two strains of laboratory mouse
www.plosone.org
www.plosone.org
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(humidity)Tj
3.9118 0 Td
(approximately)Tj
5.9753 0 Td
(4565%.)Tj
3.6227 0 Td
(The)Tj
1.7802 0 Td
(ani-)Tj
-35.1097 -1.2982 Td
(mal)Tj
1.7177 0 Td
(facility)Tj
2.897 0 Td
(was)Tj
1.7008 0 Td
(monitored)Tj
4.4901 0 Td
(for)Tj
1.3889 0 Td
(pathogenic)Tj
4.6318 0 Td
(and)Tj
1.7291 0 Td
(opportunistic)Tj
5.6296 0 Td
(pathogens)Tj
4.303 0 Td
(on)Tj
1.2755 0 Td
(a)Tj
0.6577 0 Td
(routine)Tj
3.1634 0 Td
(basis)Tj
2.1487 0 Td
(as)Tj
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(for)Tj
1.3832 0 Td
(the)Tj
1.4741 0 Td
(FELASA)Tj
3.6963 0 Td
(recommendations/guidelin)Tj
10.885 0 Td
(es)Tj
1.0034 0 Td
(\(quarterly)Tj
4.1953 0 Td
(and)Tj
1.7291 0 Td
(annual)Tj
2.9594 0 Td
(monitoring\).)Tj
5.3858 0 Td
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1.3946 0 Td
(cages)Tj
-34.1062 -1.3039 Td
(were)Tj
2.1203 0 Td
(changed)Tj
3.5716 0 Td
(every)Tj
2.3471 0 Td
(14)Tj
1.1735 0 Td
(days)Tj
1.9956 0 Td
(after)Tj
2.0352 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(week,)Tj
2.4718 0 Td
(inspected)Tj
4.0081 0 Td
(daily,)Tj
2.3754 0 Td
(and)Tj
1.7292 0 Td
(mice)Tj
2.1543 0 Td
(were)Tj
2.1259 0 Td
(provided)Tj
3.8155 0 Td
(with)Tj
-35.2004 -1.2983 Td
(100g/cage)Tj
4.1839 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(same)Tj
2.2563 0 Td
(bedding)Tj
3.4866 0 Td
(material)Tj
3.515 0 Td
(\(soft)Tj
2.0125 0 Td
(wood:)Tj
2.6703 0 Td
(Lignocel)Tj
3.6396 0 Td
(3/4-S,)Tj
2.5512 0 Td
(J.)Tj
0.7767 0 Td
(Rettenmaier)Tj
5.1477 0 Td
(&)Tj
0.9297 0 Td
(So)Tj
0 Tc
0.5386 0 Td
()Tj
-0.004 Tc
0.4422 0 Td
(hne)Tj
-34.6391 -1.2983 Td
(GmbH)Tj
3.0273 0 Td
(+)Tj
0.7994 0 Td
(Co.)Tj
1.6157 0 Td
(KG,)Tj
1.8369 0 Td
(Rosenberg\),)Tj
5.0116 0 Td
(ad)Tj
1.1849 0 Td
(libitum)Tj
3.1521 0 Td
(food)Tj
2.0466 0 Td
(\(Global)Tj
3.2201 0 Td
(Diet)Tj
1.9446 0 Td
(2018S,)Tj
2.8233 0 Td
(Harlan)Tj
3.0217 0 Td
(Italy,)Tj
2.2167 0 Td
(S.)Tj
0.9184 0 Td
(Pietro)Tj
2.6475 0 Td
(al)Tj
-35.4668 -1.3039 Td
(Natisone,)Tj
4.0195 0 Td
(Italy\))Tj
2.3357 0 Td
(and)Tj
1.7291 0 Td
(water.)Tj
2.6532 0 Td
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1.2076 0 Td
(the)Tj
1.4683 0 Td
(end)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3925 0 Td
(all)Tj
1.1451 0 Td
(mice)Tj
2.1544 0 Td
(were)Tj
2.1203 0 Td
(euthanased)Tj
4.7281 0 Td
(by)Tj
1.1792 0 Td
(exposure)Tj
3.8211 0 Td
(to)Tj
-35.155 -1.2982 Td
(CO)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 214.0724 549.7511 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 219.8551 551.3952 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(according)Tj
4.1895 0 Td
(to)Tj
1.0262 0 Td
(institutional)Tj
5.0853 0 Td
(protocol.)Tj
3.8267 0 Td
(Euthanasia)Tj
4.6205 0 Td
(was)Tj
1.6951 0 Td
(performed)Tj
4.473 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(dedicated)Tj
4.0705 0 Td
(box/cham-)Tj
-32.6605 -1.2982 Td
(ber)Tj
1.5194 0 Td
(with)Tj
2.0011 0 Td
(CO)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 249.2787 536.7118 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 252.8503 538.4125 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(using)Tj
2.3868 0 Td
(a)Tj
0.6519 0 Td
(gradual)Tj
3.2258 0 Td
(20%)Tj
1.9333 0 Td
(vol/min)Tj
3.3902 0 Td
(displacement)Tj
5.5105 0 Td
(rate.)Tj
1.9729 0 Td
(Procedures)Tj
4.7168 0 Td
(involving)Tj
3.9798 0 Td
(animals)Tj
-33.4995 -1.3039 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.109 0 Td
(care)Tj
1.8707 0 Td
(were)Tj
2.1203 0 Td
(conducted)Tj
4.4277 0 Td
(in)Tj
1.0375 0 Td
(conformity)Tj
4.7055 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(institutional)Tj
5.0853 0 Td
(guidelines)Tj
4.2803 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(Mario)Tj
-33.2558 -1.2982 Td
(Negri)Tj
2.4831 0 Td
(Institute)Tj
3.5829 0 Td
(in)Tj
1.0375 0 Td
(compliance)Tj
4.8302 0 Td
(with)Tj
1.9956 0 Td
(national)Tj
3.5036 0 Td
(\(Decreto)Tj
3.7417 0 Td
(Legge)Tj
2.5341 0 Td
(nr)Tj
1.1396 0 Td
(116/92,)Tj
3.1577 0 Td
(Gazzetta)Tj
3.6454 0 Td
(Ufficiale,)Tj
3.821 0 Td
(sup-)Tj
-35.4724 -1.2983 Td
(plement)Tj
3.4979 0 Td
(40,)Tj
1.3947 0 Td
(February)Tj
3.838 0 Td
(18,)Tj
1.3946 0 Td
(1992;)Tj
2.3471 0 Td
(Circolare)Tj
3.9288 0 Td
(nr)Tj
1.1395 0 Td
(8,)Tj
0.9241 0 Td
(Gazzetta)Tj
3.6453 0 Td
(Ufficiale,)Tj
3.8211 0 Td
(July)Tj
1.7801 0 Td
(14,)Tj
1.3947 0 Td
(1994\))Tj
2.4604 0 Td
(and)Tj
1.7348 0 Td
(interna-)Tj
-33.3011 -1.2983 Td
(tional)Tj
2.5172 0 Td
(laws)Tj
1.9502 0 Td
(and)Tj
1.729 0 Td
(policies)Tj
3.2315 0 Td
(\(EEC)Tj
2.3641 0 Td
(Council)Tj
3.4015 0 Td
(Directive)Tj
3.8834 0 Td
(2010/63/EU)Tj
5.04 0 Td
(2010;)Tj
2.3471 0 Td
(Guide)Tj
2.6815 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4684 0 Td
(Care)Tj
2.1146 0 Td
(and)Tj
1.7291 0 Td
(Use)Tj
-35.8466 -1.3039 Td
(of)Tj
1.0148 0 Td
(Laboratory)Tj
4.643 0 Td
(Animals,)Tj
3.8041 0 Td
(U.S.)Tj
1.8822 0 Td
(National)Tj
3.6907 0 Td
(Research)Tj
3.8097 0 Td
(Council)Tj
3.4016 0 Td
(\(Eighth)Tj
3.2144 0 Td
(Edition\))Tj
3.5433 0 Td
(2011\).)Tj
2.6929 0 Td
(The)Tj
1.7802 0 Td
(animal)Tj
-33.4769 -1.2982 Td
(experiment)Tj
4.7792 0 Td
(described)Tj
4.0477 0 Td
(here)Tj
1.9673 0 Td
(was)Tj
1.7007 0 Td
(reviewed)Tj
3.7928 0 Td
(and)Tj
1.7348 0 Td
(approved)Tj
3.9684 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4684 0 Td
(Mario)Tj
2.6929 0 Td
(Negri)Tj
2.4831 0 Td
(Animal)Tj
3.2201 0 Td
(Care)Tj
2.109 0 Td
(and)Tj
-35.1493 -1.2983 Td
(Use)Tj
1.7405 0 Td
(Committee)Tj
4.7394 0 Td
(\(IACUC\))Tj
3.9854 0 Td
(that)Tj
1.7802 0 Td
(includes)Tj
3.5433 0 Td
(members)Tj
3.9458 0 Td
("ad)Tj
1.5023 0 Td
(hoc")Tj
1.9956 0 Td
(for)Tj
1.389 0 Td
(ethical)Tj
2.8403 0 Td
(issues.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 418.6771 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Experimental)Tj
5.863 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 401.7259 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Mice)Tj
2.228 0 Td
(were)Tj
2.1203 0 Td
(randomly)Tj
4.1272 0 Td
(allocated)Tj
3.7644 0 Td
(to)Tj
1.0204 0 Td
(IVC)Tj
1.9219 0 Td
(\(individually)Tj
5.3291 0 Td
(ventilated\))Tj
4.4787 0 Td
(cages)Tj
2.3301 0 Td
(\(cage)Tj
2.3074 0 Td
(model)Tj
2.7439 0 Td
(GM500,)Tj
-32.3714 -1.3039 Td
(usable)Tj
2.7099 0 Td
(surface)Tj
3.0443 0 Td
(500cm)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 284.2582 393.1653 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 287.8299 388.6866 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4365 0 Td
(overall)Tj
2.897 0 Td
(dimensions)Tj
4.8472 0 Td
(\(W)Tj
1.5193 0 Td
(x)Tj
0.6804 0 Td
(D)Tj
0.9467 0 Td
(x)Tj
0.6803 0 Td
(H\):)Tj
1.5477 0 Td
(391)Tj
1.6385 0 Td
(x)Tj
0.6803 0 Td
(199)Tj
1.6384 0 Td
(x)Tj
0.6803 0 Td
(160)Tj
1.6384 0 Td
(mm,)Tj
2.0806 0 Td
(ventilated)Tj
4.1386 0 Td
(in)Tj
1.0261 0 Td
(pos-)Tj
-35.8579 -1.2982 Td
(itive)Tj
1.9275 0 Td
(mode)Tj
2.5002 0 Td
(at)Tj
0.9524 0 Td
(75)Tj
1.1735 0 Td
(air)Tj
1.287 0 Td
(changes)Tj
3.4071 0 Td
(per)Tj
1.5307 0 Td
(hour)Tj
2.1543 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6576 0 Td
(differential)Tj
4.6034 0 Td
(rate)Tj
1.7462 0 Td
(of)Tj
1.0148 0 Td
(-20%)Tj
2.279 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(air)Tj
1.2926 0 Td
(exhausted,)Tj
4.4334 0 Td
(Tec-)Tj
-35.4384 -1.2983 Td
(niplast)Tj
2.8913 0 Td
(S.p.A.,)Tj
2.8006 0 Td
(Buguggiate)Tj
4.6714 0 Td
(\(VA\))Tj
2.279 0 Td
(Italy\))Tj
2.3357 0 Td
(in)Tj
1.0319 0 Td
(single-strain)Tj
5.1646 0 Td
(groups)Tj
2.9707 0 Td
(of)Tj
1.0148 0 Td
(four)Tj
1.9106 0 Td
(individuals.)Tj
4.8755 0 Td
(Each)Tj
2.177 0 Td
(cage)Tj
-34.1231 -1.3039 Td
(position)Tj
3.4922 0 Td
(was)Tj
1.7008 0 Td
(fitted)Tj
2.3187 0 Td
(with)Tj
1.9955 0 Td
(an)Tj
1.2076 0 Td
(integrated)Tj
4.2746 0 Td
(EMF)Tj
2.211 0 Td
(plate)Tj
2.1373 0 Td
(\(DVC)Tj
/F11 1 Tf
[()]TJ
/F5 1 Tf
3.1068 0 Td
(plate,)Tj
2.364 0 Td
(Tecniplast)Tj
4.354 0 Td
(SpA\).with)Tj
4.2406 0 Td
(a)Tj
0.652 0 Td
(potential)Tj
-34.0551 -1.2983 Td
(frequency)Tj
4.1839 0 Td
(range)Tj
2.4661 0 Td
(of)Tj
1.0148 0 Td
(5-100Hz,)Tj
3.8777 0 Td
(but)Tj
1.5534 0 Td
(with)Tj
1.9955 0 Td
(either)Tj
2.5342 0 Td
(the)Tj
1.4683 0 Td
(EMF)Tj
2.211 0 Td
(plate)Tj
2.1373 0 Td
(turned)Tj
2.9197 0 Td
(`on')Tj
1.7121 0 Td
(\(experimental)Tj
5.7997 0 Td
(group,)Tj
-33.8737 -1.2982 Td
(n)Tj
0.7653 0 Td
(=)Tj
0.7994 0 Td
(5)Tj
0.6973 0 Td
(cages/strain\))Tj
5.2781 0 Td
(or)Tj
1.0998 0 Td
(turned)Tj
2.9139 0 Td
(`off')Tj
1.7461 0 Td
(\(control)Tj
3.4583 0 Td
(group,)Tj
2.8346 0 Td
(n)Tj
0.771 0 Td
(=)Tj
0.7994 0 Td
(5)Tj
0.6973 0 Td
(cages/strain\).)Tj
5.4992 0 Td
(We)Tj
1.6101 0 Td
(measured)Tj
4.1102 0 Td
(the)Tj
-33.08 -1.3039 Td
(strength)Tj
3.5149 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(EMF)Tj
2.2111 0 Td
(in)Tj
1.0317 0 Td
(the)Tj
1.474 0 Td
(specified)Tj
3.7133 0 Td
(range)Tj
2.4662 0 Td
(\(5-100Hz\),)Tj
4.558 0 Td
(by)Tj
1.1792 0 Td
(placing)Tj
3.1238 0 Td
(the)Tj
1.4683 0 Td
(antenna)Tj
3.4583 0 Td
(of)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(electric)Tj
3.0954 0 Td
(and)Tj
-35.994 -1.2983 Td
(magnetic)Tj
3.9004 0 Td
(field)Tj
1.9729 0 Td
(analyser)Tj
3.4922 0 Td
(\(model)Tj
3.0841 0 Td
(EHP-50,)Tj
3.6396 0 Td
(Narda\))Tj
3.0671 0 Td
(into)Tj
1.8368 0 Td
(the)Tj
1.474 0 Td
(centre)Tj
2.7043 0 Td
(of)Tj
1.0204 0 Td
(each)Tj
2.024 0 Td
(cage,)Tj
2.194 0 Td
(close)Tj
2.1826 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(floor,)Tj
-35.0869 -1.2983 Td
(when)Tj
2.4037 0 Td
(all)Tj
1.1452 0 Td
(the)Tj
1.4684 0 Td
(designated)Tj
4.4956 0 Td
(EMF)Tj
2.211 0 Td
(`on')Tj
1.7178 0 Td
(plates)Tj
2.5001 0 Td
(were)Tj
2.1203 0 Td
(turned)Tj
2.9197 0 Td
(on.)Tj
1.5023 0 Td
(The)Tj
1.7802 0 Td
(average)Tj
3.2258 0 Td
(value)Tj
2.3074 0 Td
(recorded)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
-34.6277 -1.3039 Td
(EMF)Tj
2.211 0 Td
(`on')Tj
1.7121 0 Td
(cages)Tj
2.3301 0 Td
(at)Tj
0.9524 0 Td
(this)Tj
1.6723 0 Td
(point)Tj
2.3584 0 Td
(was)Tj
1.7008 0 Td
(8.56V/m)Tj
3.7134 0 Td
(as)Tj
1.0148 0 Td
(r.m.s)Tj
2.2223 0 Td
(\(+/-)Tj
1.8199 0 Td
(0.77)Tj
1.8708 0 Td
(SE\))Tj
1.6101 0 Td
(and)Tj
1.7291 0 Td
(4.99V/m)Tj
3.7134 0 Td
(r.m.s.)Tj
2.4491 0 Td
(\(+/-)Tj
1.8198 0 Td
(0.32)Tj
-34.8998 -1.2983 Td
(SE\))Tj
1.6044 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(EMF)Tj
2.211 0 Td
(`off')Tj
1.7405 0 Td
(cages.)Tj
2.551 0 Td
(The)Tj
1.7858 0 Td
(cages)Tj
2.3244 0 Td
(were)Tj
2.126 0 Td
(positioned)Tj
4.4447 0 Td
(within)Tj
2.8119 0 Td
(a)Tj
0.652 0 Td
(cage)Tj
1.9672 0 Td
(rack)Tj
1.9446 0 Td
(modified)Tj
3.8494 0 Td
(to)Tj
1.0205 0 Td
(accom-)Tj
-33.5392 -1.2982 Td
(modate)Tj
3.2314 0 Td
(EMF)Tj
2.2054 0 Td
(plates)Tj
2.5001 0 Td
(such)Tj
2.0635 0 Td
(that)Tj
1.7745 0 Td
(cages)Tj
2.3301 0 Td
(were)Tj
2.1203 0 Td
(distributed)Tj
4.5977 0 Td
(evenly)Tj
2.7723 0 Td
(throughout)Tj
4.7792 0 Td
(the)Tj
1.4683 0 Td
(rack)Tj
1.9446 0 Td
(for)Tj
1.389 0 Td
(both)Tj
2.0579 0 Td
(strain)Tj
-35.2343 -1.2983 Td
(\(C57BL/6NCrl)Tj
6.1114 0 Td
(and)Tj
1.7348 0 Td
(BALB/cAnNCrl\))Tj
6.9448 0 Td
(and)Tj
1.7291 0 Td
(condition)Tj
4.1159 0 Td
(\(i.e.)Tj
1.7007 0 Td
(EMF)Tj
2.211 0 Td
(`on'/'off'\))Tj
3.8948 0 Td
(to)Tj
1.0262 0 Td
(avoid)Tj
2.4094 0 Td
(any)Tj
1.6611 0 Td
(positional)Tj
-33.5392 -1.3039 Td
(bias)Tj
1.7858 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(Fig)Tj
1.4797 0 Td
(1)Tj
0 g
(\),)Tj
1.2642 0 Td
(and)Tj
1.7291 0 Td
(with)Tj
1.9955 0 Td
(empty)Tj
2.7326 0 Td
(spaces)Tj
2.7439 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(rack)Tj
1.9446 0 Td
(surrounding)Tj
5.244 0 Td
(each)Tj
2.024 0 Td
(individual)Tj
4.2916 0 Td
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